Journal
SENSORS AND ACTUATORS B-CHEMICAL
Volume 257, Issue -, Pages 792-799Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2017.11.004
Keywords
Cu-BTC MOFs; Macroporous carbon; AuNPs; Glucose oxidase; Glucose; Ratiometric electrochemical biosensor
Funding
- National Natural Science Foundation of China [21465014, 21465015, 21665012, 21765009]
- Natural Science Foundation of Jiangxi Province [20143ACB21016]
- Ministry of Education [20133604110002]
- Jiangxi Educational Committee [KJLD14023]
- Innovation Fund Project of Jiangxi [YC2017-S131]
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Cu-trimesic acid metal-organic frameworks (Cu-BTC MOFs) were firstly grown on three-dimensional macroporous carbon integrated electrode (3D-KSCs), then Au nanoparticles (AuNPs) were electrodeposited on Cu-BTC MOFs/3D-KSCs electrode and finally glucose oxidase (GOD) was immobilized to construct a ratiometric electrochemical glucose biosensor. Scanning electron microscopy was employed to monitor the modified process of GOD/AuNPs/Cu-BTC MOFs/3D-KSCs electrode. Electrochemical techniques were applied to explore the electrochemical behaviors of GOD/AuNPs/Cu-BTC MOFs/3D-KSCs electrode, which showed the reduction peaks of O-2 and Cu-BTC MOFs. The reduction peak current density of O2 decreased and the reduction peak current density of Cu-BTC MOFs increased with the increase of glucose concentration less than 4 mM. However, the reduction peak current of O-2 was still declined while the reduction peak current of Cu-BTC MOFs maintained constant with the addition of glucose beyond 4 mM. The j(O2)/j(Cu-BTC) was considered as the response signal which exhibited a good linear range with the glucose concentration from 44.9 mu M to 4.0 mM and from 4.0 to 19 mM, and the detection limit was 14.77 mu M. The as-prepared biosensor also showed high accuracy, high selectivity and good reproducibility. The work gave a first example to use electroactive MOFs as reference signal for ratiometric electrochemical sensor. (c) 2017 Elsevier B.V. All rights reserved.
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