Journal
SENSORS
Volume 18, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/s18072309
Keywords
luteolin; gold nanocages; carbon ionic liquid electrode; electrochemistry
Funding
- Program for Innovative Research Team in University [IRT-16R19]
- National Natural Science Foundation of Hainan Province of China [2017CXTD007]
- Special Projects of the Central Government for the Development of Local Science and Technology [ZY2018HN07]
- Graduate Student Innovation Research Project of Hainan Province [Hyb2017-35]
- Research Project of Hainan Provincial Department of Education [Hnky2017-21]
- Key Science and Technology Program of Haikou City [2017042]
- Foundation of Key Laboratory of Sensor Analysis of Tumor Marker of Ministry of Education of Qingdao University of Science and Technology [STAM201808]
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A simple and sensitive electrochemical sensor was developed for the detection of tracelevels of luteolin. The sensoris based on a novel type of chemically modified electrode: gold nanocage (AuNCs)-modified carbon ionic liquid electrode (CILE). To construct this electrochemical sensing platform for luteolin, CILE is initially prepared by using 1-hexylpyridinium hexafluorophosphate as the binder and then AuNCs are coated on the surface of CILE to fabricate AuNCs-modified CILE (AuNCs/CILE). Electrochemical studies have shown that AuNCs/CILE can exhibit enhanced electrocatalytic activity toward the redox reaction of luteolin, therefore, the redox peak current of luteolin can be greatly improved, resulting in the high sensitivity of the developed sensor. Under the optimal conditions, the oxidation peak currents of the sensor increase linearly with an increase in the luteolin concentration in a range from 1 to 1000 nM with a detection limit of 0.4 nM, which is lower than those of most reported electrochemical luteolin sensors. Moreover, the reproducibility, precision, selectivity, and stability of this sensor are excellent. Finally, the sensing system was applied to the analysis of luteolin-spiked drug samples and the recovery in all cases was 95.0-96.7%, indicating the potential application of this simple, facile, and sensitive sensing system in pharmaceutical analysis.
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