Journal
SEMINARS IN RADIATION ONCOLOGY
Volume 28, Issue 1, Pages 46-52Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semradonc.2017.08.002
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Funding
- Newman Family Foundation
- NIH, United States [RO1 CA-184153]
- NATIONAL CANCER INSTITUTE [R01CA184153] Funding Source: NIH RePORTER
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This is an overview of select studies characterizing the effect of radiation on normal tissues in the treatment of head-and-neck cancer. Recommendations for organ-at-risk dose constraints aiming to reduce risks of xerostomia and dysphagia, the factors which have the highest effect on patient quality of life, are discussed, along with their supporting evidence. Recent advances in technology and biology, and their implications for reducing toxicity are explored. Considerations related to organ-sparing in the setting of treatment deintensification for good prognosis head-and-neck cancer are also discussed. (C) 2017 Published by Elsevier Inc.
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