Journal
SEMINARS IN PEDIATRIC SURGERY
Volume 27, Issue 1, Pages 39-46Publisher
ELSEVIER SCIENCE INC
DOI: 10.1053/j.sempedsurg.2017.11.008
Keywords
Preterm; Neonate; Bacteria; Microbiome; Gut; Meta-analysis
Categories
Funding
- NIH [KL2 TR000455, UL1 TR000454, K23 HL128942, R01 HD059127]
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In this review, we summarize existing knowledge regarding the effects of probiotics on necrotizing enterocolitis (NEC). We review the role of the microbiome in NEC and pre-clinical data on mechanisms of probiotic action. Next, we summarize existing randomized controlled trials and observational studies of probiotics to prevent NEC. We also summarize findings from several recent meta-analyses and report a new cumulative meta-analysis of probiotic trials. Finally, we review data from cohorts routinely using commercially available probiotics. Our goal is to inform clinicians about the risks and benefits of probiotics, which may be helpful for those considering use in preterm infants to prevent NEC, death, or sepsis. (C) 2018 Elsevier Inc. All rights reserved.
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