Journal
SEMINARS IN NEPHROLOGY
Volume 38, Issue 3, Pages 233-250Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.semnephrol.2018.02.004
Keywords
Chronic kidney disease; vascular calcification; promoters; inhibitors; treatments
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Funding
- Recherche hospitalo-Universitaire project Search Treatment and improve Outcome of Patients with Aortic Stenosis
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In chronic kidney disease (CKD), the progressive decrease in renal function leads to disturbances of mineral metabolism that generally cause secondary hyperparathyroidism. The increase in serum parathyroid hormone is associated with reduced serum calcium and calcitriol levels and/or increased serum fibroblast growth factor-23 and phosphate levels. The resulting CKD-associated disorder of mineral and bone metabolism is associated with various other metabolic dysregulations such as acidosis, malnutrition, inflammation, and accumulation of uremic toxins. It favors the occurrence of vascular calcification, which results from an imbalance between numerous inhibitors and promoters of soft-tissue mineralization. This review provides an overview of the most recent state of knowledge concerning the mechanisms that lead to the development of vascular calcification in the CKD setting. It further proposes directions for potential new therapeutic targets. Semin Nephrol 38:233-250 (C) 2018 Elsevier Inc. All rights reserved.
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