Journal
JOURNAL OF APICULTURAL SCIENCE
Volume 56, Issue 2, Pages 107-113Publisher
RESEARCH INST POMOLOGY FLORICULTURE, DIV APICULTURE
DOI: 10.2478/v10289-012-0028-4
Keywords
amphotericin B; Apis mellifera; DNA methylation; life-span; protein concentration
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Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup with AmB in a dose of 0.25 mg/ml. Amphotericin B shortened the life span of the bees and reduced the level of global DNA methylation compared to the control, however, it increased the body-surface protein concentrations. In the hindguts of the bees, there were found AmB deposits. Honeybees appear to be a useful model for studying the side effects of anti-fungal AmB therapy. Among other things, epigenetic changes and senescence acceleration are considered to be the side effects of the therapy.
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