Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 40, Issue 4, Pages 371-377Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-018-0694-9
Keywords
Innate lymphoid cells; ILCs; Aryl hydrocarbon receptor; AHR; DP IEL
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Funding
- Rainin Foundation, NIH [U01 AI095542, DK103039]
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The intestinal immune system is challenged daily with the task of recognizing and eliminating pathogens while simultaneously tolerating dietary and commensal antigens. All components must effectively coordinate to differentiate a continual barrage of environmental cues and mount appropriate responses dependent on the nature of the stimuli encountered. Playing a pivotal role, the aryl hydrocarbon receptor (AHR) is a chemical sensor that detects both dietary and microbial cues and is important for development, maintenance, and function of several types of intestinal immune cells, particularly innate lymphoid cells (ILCs) and T cells. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in ILCs, T cells, B cells, and dendritic cells.
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