Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 80, Issue -, Pages 65-73Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.08.015
Keywords
Regeneration; Hydrogen peroxide; Nerves; Shh
Categories
Funding
- ANR [ANR-10-LABX-54 MEMO LIFE - ANR-11-IDEX-0001-02 PSL*]
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The tight control of reactive oxygen species (ROS) levels is required during regeneration. H2O2 in particular assumes clear signalling functions at different steps in this process. Injured nerves induce high levels of H2O2 through the activation of the Hedgehog (Shh) pathway, providing an environment that promotes cell plasticity, progenitor recruitment and blastema formation. In turn, high H2O2 levels contribute to growing axon attraction. Once re-innervation is completed, nerves subsequently downregulate H2O2 levels to their original state. A similar regulatory loop between H2O2 levels and nerves also exists during development. This suggests that redox signalling is a major actor in cell plasticity. (C) 2017 Elsevier Ltd. All rights reserved.
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