Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 79, Issue -, Pages 131-142Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2017.11.001
Keywords
Nuclear retention; mRNPs; Selective mRNA export; Nuclear speckles; Paraspeckles; SR proteins; Post-transcriptional splicing; NXF1; Detained introns; Quality control
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Funding
- German Research Foundation (DFG) (CEF-MC)
- German Research Foundation (DFG) [SFB902]
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Nuclear retention of incompletely spliced or mature mRNAs emerges as a novel, previously underap-preciated layer of gene regulation, which enables the cell to rapidly respond to stress, viral infection, differentiation cues or changing environmental conditions. Focusing on mammalian cells, we discuss recent insights into the mechanisms and functions of nuclear retention, describe retention-promoting features in protein-coding transcripts and propose mechanisms for their regulated release into the cytoplasm. Moreover, we discuss examples of how aberrant nuclear retention of mRNAs may lead to human diseases. (C) 2017 Elsevier Ltd. All rights reserved.
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