Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 86, Issue -, Pages 162-173Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2018.03.013
Keywords
GAPDH; RNA-binding protein; Metabolism; Translational repressor; mRNA stability; Post-transcriptional regulation
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Funding
- UMBC/UMB Research and Innovation Partnership Grant Innovation Seed Track
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Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) plays a key role in glycolysis but is also known for its involvement in a myriad of extra-glycolytic functions. While GAPDH is not the only enzyme with established moonlighting roles, it shows great diversity in terms of its functions, cellular localizations, protein partners, and post-translational modifications. This review focuses on GAPDH's role as a non-canonical RNA binding protein to regulate the stability and translation of cellular mRNAs. Despite the clear involvement of GAPDH in gene expression regulation, how and where GAPDH binds to its RNA targets is still unknown. In addition, the mechanism by which GAPDH switches among its various cellular functions is also unknown. This review will summarize our current understanding of GAPDH-mediated regulation of RNA function. (C) 2018 Elsevier Ltd. All rights reserved.
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