Journal
SCIENCE TRANSLATIONAL MEDICINE
Volume 10, Issue 442, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.aaq1011
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Funding
- Center on the Physics of Cancer Metabolism through National Cancer Institute [1U54CA210184-01]
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Patient-derived culture models enable assessment of drug sensitivity and can connect personalized genomics with therapeutic options. However, their clinical translation is constrained by limited fidelity. We outline how the physical microenvironment regulates cell metabolism and describe how engineered culture systems could enhance the predictive power for precision medicine.
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