Journal
SCIENCE OF THE TOTAL ENVIRONMENT
Volume 624, Issue -, Pages 1-8Publisher
ELSEVIER
DOI: 10.1016/j.scitotenv.2017.12.107
Keywords
Triclosan; Detoxification mechanism; Cytochrome P450; Glutathione S-transferase; Multidrug resistance-associated protein 1
Categories
Funding
- Plan Nacional de Investigacion Cientifica, Desarrollo e Innovacion Tecnologica (Spain) from the Ciencias y Tecnologias Medioambientales program [CTM2015-64913-R]
Ask authors/readers for more resources
Triclosan (TCS) is an antimicrobial agent used in a range of personal care and consumer products and is commonly detected in aquatic ecosystems. In the present study, the effects of TCS at the molecular level on the detoxification system of Chironomus riparius aquatic larvae, a test organism widely used for the assessment of aquatic toxicology, were evaluated. The obtained results show that this xenobiotic was able to induce significant changes in transcripts from different cytochrome P450s and glutathione s-transferases genes, involved in phase I and phase II of detoxification system, respectively. In contrast, TCS did not affect the glutathione S-transferase enzyme activity nor the expression pattern of multidrug resistance-associated protein 1, which belongs to phase III of detoxification system. These results provide information about the effects of TCS on the detoxification mechanism of C. riparius and offers different biomarker genes that could be useful in ecotoxicological studies, risk assessment and bioremediation. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available