Journal
JOURNAL OF BIOMEDICAL SCIENCE
Volume 19, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1423-0127-19-102
Keywords
Hypoxia; Hypoxia-inducible factor; Target genes; Metastasis; Epithelial-mesenchymal transition
Categories
Funding
- National Science Council [NSC101-2321-B-010-002]
- National Research Program for Biopharmaceuticals [NSC101-2325-B-010-004]
- Ministry of Education
- Aim for the Top University Plan [101AC-T505]
- center of excellence for cancer research at Taipei Veterans General Hospital [DOH101-TD-C-111-007]
- Taichung Veterans General Hospital [TCVGH-YM1000301, TCVGH-YM1010301]
- National Health Research Institutes [NHRI-EX101-9931BI]
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Hypoxia is an important microenvironmental factor that induces cancer metastasis. Hypoxia/hypoxia-inducible factor-1 alpha (HIF-1 alpha) regulates many important steps of the metastatic processes, especially epithelial-mesenchymal transition (EMT) that is one of the crucial mechanisms to cause early stage of tumor metastasis. To have a better understanding of the mechanism of hypoxia-regulated metastasis, various hypoxia/HIF-1 alpha-regulated target genes are categorized into different classes including transcription factors, histone modifiers, enzymes, receptors, kinases, small GTPases, transporters, adhesion molecules, surface molecules, membrane proteins, and microRNAs. Different roles of these target genes are described with regards to their relationship to hypoxia-induced metastasis. We hope that this review will provide a framework for further exploration of hypoxia/HIF-1 alpha-regulated target genes and a comprehensive view of the metastatic picture induced by hypoxia.
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