Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 61, Issue 6, Pages 651-659Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-017-9243-0
Keywords
Mycobacterium tuberculosis; Lineage 2; Lineage 4; large sequence polymorphism; fever
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Funding
- National Natural Science Foundation of China [81273144]
- Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education [KZ201510025024]
- Fundamental Research Funds for the Central Universities [2017JBM071]
- China Postdoctoral Science Foundation [2017M620595]
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The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.
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