Journal
SCIENCE CHINA-LIFE SCIENCES
Volume 61, Issue 4, Pages 448-456Publisher
SCIENCE PRESS
DOI: 10.1007/s11427-017-9287-8
Keywords
temperature; magnetic nanocomposite hydrogel; mesenchymal stem cell; osteogenic differentiation
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Funding
- National Natural Science Foundation of China [81671829]
- 111 Project [B17026]
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Hyperthermia has been considered as a promising healing treatment in bone regeneration. We designed a tissue engineering hydrogel based on magnetic nanoparticles to explore the characteristics of hyperthermia for osteogenic regeneration. This nanocomposite hydrogel was successfully fabricated by incorporating magnetic Fe3O4, nanoparticles into chitosan/polyethylene glycol (PEG) hydrogel, which showed excellent biocompatibility and were able to easily achieve increasing temperatures under an alternative magnetic field (AMF). With uniformly dispersed nanoparticles, the composite hydrogel resulted in high viability of mesenchymal stem cells (MSCs), and the elevated temperature contributed to the highest osteogenic differentiation ability compared with direct heat treatment applied under equal temperatures. Therefore, the nanoheat stimulation method using the magnetic nanocomposite hydrogel under an AMF may be considered as an alternative candidate in bone tissue engineering regenerative applications.
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