Journal
SCIENCE
Volume 359, Issue 6377, Pages 759-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aao4798
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Funding
- Scripps Research Institute (TSRI)
- NIH (National Institute of General Medical Sciences) [2R01GM084019]
- Bristol-Myers Squibb
- NSF under the Centers for Chemical Innovation Center for Selective C-H Functionalization [CHE-1205646]
- NSF
- TSRI
- Boehringer Ingelheim
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM084019] Funding Source: NIH RePORTER
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Organic molecules are rich in carbon-hydrogen bonds; consequently, the transformation of C-H bonds to new functionalities (such as C-C, C-N, and C-O bonds) has garnered much attention by the synthetic chemistry community. The utility of C-H activation in organic synthesis, however, cannot be fully realized until chemists achieve stereocontrol in the modification of C-H bonds. This Review highlights recent efforts to enantioselectively functionalize C(sp(3))-H bonds via transition metal catalysis, with an emphasis on key principles for both the development of chiral ligand scaffolds that can accelerate metalation of C(sp(3))-H bonds and stereomodels for asymmetric metalation of prochiral C-H bonds by these catalysts.
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