Journal
SCIENCE
Volume 360, Issue 6394, Pages 1239-+Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aas9875
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Funding
- Swiss National Science Foundation [31003A_155898]
- National Competence Center for Research Synapsy
- European Research Council [ERC-2015-StG 678832]
- NARSAD [24497]
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Whether fear attenuation is mediated by inhibition of the original memory trace of fear with a new memory trace of safety or by updating of the original fear trace toward safety has been a long-standing question in neuroscience and psychology alike. In particular, which of the two scenarios underlies the attenuation of remote (month-old) fear memories is completely unknown, despite the impetus to better understand this process against the backdrop of enduring traumata. We found-chemogenetically and in an engram-specific manner-that effective remote fear attenuation is accompanied by the reactivation of memory recall-induced neurons in the dentate gyrus and that the continued activity of these neurons is critical for fear reduction. This suggests that the original memory trace of fear actively contributes to remote fear attenuation.
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