Journal
SCIENCE
Volume 360, Issue 6390, Pages 739-742Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aap7999
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Funding
- Natural Environmental Research Council (NERC) [NE/K014455/1]
- Medical Research Council (MRC) [MR/K000373/1]
- BBSRC's Industrial Strategy Challenge Fund [BBS/OS/CP/000001]
- Swiss National Science Foundation [FN 301003A-172958]
- BBSRC [BB/PO18335]
- Biotechnology and Biological Sciences Research Council [BBS/OS/CP/000001] Funding Source: researchfish
- Medical Research Council [MR/R015600/1, MR/K000373/1] Funding Source: researchfish
- Natural Environment Research Council [NE/P001165/1, NE/K014455/1] Funding Source: researchfish
- MRC [MR/R015600/1, MR/K000373/1] Funding Source: UKRI
- NERC [NE/P001165/1, NE/K014455/1] Funding Source: UKRI
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The recent rate of emergence of pathogenic fungi that are resistant to the limited number of commonly used antifungal agents is unprecedented. The azoles, for example, are used not only for human and animal health care and crop protection but also in antifouling coatings and timber preservation. The ubiquity and multiple uses of azoles have hastened the independent evolution of resistance in many environments. One consequence is an increasing risk in human health care from naturally occurring opportunistic fungal pathogens that have acquired resistance to this broad class of chemicals. To avoid a global collapse in our ability to control fungal infections and to avoid critical failures in medicine and food security, we must improve our stewardship of extant chemicals, promote new antifungal discovery, and leverage emerging technologies for alternative solutions.
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