Journal
SCIENCE
Volume 360, Issue 6384, Pages 81-85Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aar6821
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Funding
- Wellcome Trust [103714MA]
- National Institutes for Health [NS095654, MH106934]
- Medical Research Council [N012291]
- Biotechnology and Biological Sciences Research Council [N006542]
- EMBO postdoctoral fellowship
- Wellcome Trust [103714/Z/14/Z] Funding Source: Wellcome Trust
- MRC [MR/N026063/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1313956] Funding Source: researchfish
- Medical Research Council [MR/N026063/1] Funding Source: researchfish
- Wellcome Trust [103714/Z/14/Z] Funding Source: researchfish
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GABAergic interneurons (GABA, gamma-aminobutyric acid) regulate neural-circuit activity in the mammalian cerebral cortex. These cortical interneurons are structurally and functionally diverse. Here, we use single-cell transcriptomics to study the origins of this diversity in the mouse. We identify distinct types of progenitor cells and newborn neurons in the ganglionic eminences, the embryonic proliferative regions that give rise to cortical interneurons. These embryonic precursors show temporally and spatially restricted transcriptional patterns that lead to different classes of interneurons in the adult cerebral cortex. Our findings suggest that shortly after the interneurons become postmitotic, their diversity is already patent in their diverse transcriptional programs, which subsequently guide further differentiation in the developing cortex.
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