Journal
SCIENCE
Volume 359, Issue 6380, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aao5902
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Funding
- NSF Graduate Research Fellowship
- Ruth L. Kirschstein National Research Service Award [F31 CA203228-02]
- Howard Hughes Medical Institute, NIH [5R01CA163915-04]
- NIH Javits Neuroscience Investigator Award [R37 NS046789-12]
- Congressionally Directed Medical Research Program Breast Cancer Research Breakthrough Award
- Simons Foundation Autism Research Initiative
- NATIONAL CANCER INSTITUTE [R01CA163915, F31CA203228] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R37NS046789] Funding Source: NIH RePORTER
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Proximity, or the physical closeness of molecules, is a pervasive regulatory mechanism in biology. For example, most posttranslational modifications such as phosphorylation, methylation, and acetylation promote proximity of molecules to play deterministic roles in cellular processes. To understand the role of proximity in biologic mechanisms, chemical inducers of proximity (CIPs) were developed to synthetically model biologically regulated recruitment. Chemically induced proximity allows for precise temporal control of transcription, signaling cascades, chromatin regulation, protein folding, localization, and degradation, as well as a host of other biologic processes. A systematic analysis of CIPs in basic research, coupled with recent technological advances utilizing CRISPR, distinguishes roles of causality from coincidence and allows for mathematical modeling in synthetic biology. Recently, induced proximity has provided new avenues of gene therapy and emerging advances in cancer treatment.
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