Journal
ARKIVOC
Volume -, Issue -, Pages 111-121Publisher
ARKAT USA INC
DOI: 10.3998/ark.5550190.0013.910
Keywords
Pechmann; coumarins; phenols; beta-ketoesters; boric trisulfuric anhydride (BTSA); solvent-free reactions
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Funding
- Payame Noor University (PNU) research council
- Shiraz University research council
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It is found that silica supported boric trisulfuric anhydride (BTSA. SiO2) is a novel, suitable and versatile catalyst for efficient and clean synthesis of coumarins via Pechmann cyclocondensation under mild and solvent-free conditions. Different kinds of phenols and beta-ketoesters were subjected to the cyclization reaction. Particularly, this catalyst makes the condensation of less activated phenols feasible. Besides the described benefits, the reported catalyst was applied successfully for the synthesis of novel coumarins from 3-acetyldihydrofuran-2(3H)-one as well as estradiol (sex hormone).
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