Journal
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
Volume 44, Issue 1, Pages 123-127Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162018010090
Keywords
cytotoxicity; lupanes; Mannich bases; oleananes; triterpenoids
Funding
- Russian Foundation for Basic Research [16-33-60204 mol_a_dk]
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New propargylamines were synthesized in 72-75% yields by the interaction of 19-alkynylbetulin and 28-O-propargyl glycinamide of oleanolic acid with N-methylpiperazine under the Mannich reaction conditions. 19-[1-Methyl-4-prop-2-yn-1-yl-piperazine]-20,29,30-trinorbetulin was shown to manifest anticancer activity against one line of leukemia cells and two lines of colon cancer cells, whereas the growth of leukemia cells SR in the presence of 4-(4-methylpiperazin-1-yl)but-2-yn-1-yl-N-(3-hydroxy-28-oxoolean-12-en-28-yl)glycinate was 8%.
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