Journal
RUSSIAN CHEMICAL BULLETIN
Volume 67, Issue 1, Pages 95-101Publisher
SPRINGER
DOI: 10.1007/s11172-018-2042-6
Keywords
1,2,5-thiadiazole 1-oxides; sulfur monochloride; ortho-nitroamino derivatives; synthesis; nitric oxide
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Funding
- Russian Science Foundation [14-50-00126]
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A convenient one-pot synthesis of nitro derivatives of 2,1,3-benzothiadiazole 1-oxides by the reaction of o-nitroanilines with sulfur monochloride was developed. The structural features of 4-nitrobenzothiadiazole and its N-oxide were considered. High in vitro release of nitric oxide (69%) was found for a 6-nitro-2,1,3-benzothiadiazole sample by the Griess assay, which indicated good prospects for this class of compounds.
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