Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 7, Pages 3981-3993Publisher
AMER CHEMICAL SOC
DOI: 10.1021/am506516r
Keywords
gold nanoshells; catheter-related infections; polydimethylsiloxane; surface plasmon resonance; E. faecalis; photothermal
Funding
- Robert A. Welch Foundation [E-1320]
- National Science Foundation [DMR-1207583]
- Texas Center for Superconductivity
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1207583] Funding Source: National Science Foundation
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Catheter-related,infections, (CRIs) are associated with the formation of pathogenic biofilms on the surfaces of silicone Catheters, which are ubiquitous in medicine. These biofilms provide protection against antimicrobial agents and facilitate the development of bacterial resistance to antibiotics. The application of photothermal agents on catheter surfaces is, an innovative approach to,overcoming biofilm-generated CRIs. Cold nanoshells (AuNSs) represent a promising photothermal tool, because they can be used to generate heat upon exposure to near-infrared (NIR) radiation, are biologically inert at physiological temperatures, and can be engineered for the photothermal ablation of cells and tissue. In this study, AuNSs functionalized with carboxylate-terminated organosulfur ligands Were attached to model catheter surfaces and tested for their effectiveness at killing adhered Enterococcus faecalis (E. faecalis) bacteria. The morphology of the AuNSs was characterized by scanning electron microscopy (SEM) and transmission electron microscopy (TEM), while the elemental composition was characterized by energy-dispersive X-ray spectroscopy (EDX) and X-ray photoelectron spectroscopy (XPS). Furthermore, optical and photothermal properties were acquired by ultraviolet visible (UV-vis) spectroscopy and thermographic imaging with an infrared camera, respectively. Bacterial survival studies on AuNS-modified surfaces irradiated-With and without NIR light were evaluated using a colony-formation assay. These studies demonstrated that AuNS-modified surfaces, when illuminated with NIR light, can effectively kill E. faecalis on silicone surfaces.
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