Journal
REVIEWS IN MEDICAL VIROLOGY
Volume 28, Issue 3, Pages -Publisher
WILEY
DOI: 10.1002/rmv.1978
Keywords
acute disseminated encephalomyelitis; chikungunya; complications; congenital infections; encephalitis; Guillain-Barre syndrome; myelitis; neonatal infection; neurological; optic neuritis; retinitis; uveitis
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Funding
- European Union's Horizon research and innovation programme [734584]
- National Institute for Health Research Health Protection Research Unit (NIHR HPRU)
- Medical Research Council [MC_PC_15096]
- MRC [MC_PC_15096] Funding Source: UKRI
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We performed a systematic review on the neurological complications of chikungunya virus. Such complications are being reported increasingly, owing primarily to the scale of recent epidemics but also to a growing understanding of the virus' neurovirulence. We performed a thorough literature search using PubMed and Scopus databases, summating the data on all published reports of neurological disease associated with chikungunya virus. We appraised the data for each major condition in adults, children, and neonates, as well as evaluating the latest evidence on disease pathogenesis and management strategies. The review provides a comprehensive summary for clinicians, public health officials, and researchers tackling the challenges associated with this important emerging pathogen.
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