Journal
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
Volume 19, Issue 4, Pages 283-292Publisher
SPRINGER
DOI: 10.1007/s11154-018-9451-6
Keywords
Adipose tissue; Inflammation; Obesity; Innate immunity; Macrophages; Eosinophils; Innate lymphoid cells
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Funding
- Deutsche Forschungsgemeinschaft [FOR 2599, IRTG2251]
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Immune cells are present in the adipose tissue (AT) and regulate its function. Under lean conditions, immune cells predominantly of type 2 immunity, including eosinophils, M2-like anti-inflammatory macrophages and innate lymphoid cells 2, contribute to the maintenance of metabolic homeostasis within the AT. In the course of obesity, pro-inflammatory immune cells, such as M1-like macrophages, prevail in the AT. Inflammation in the obese AT is associated with the development of metabolic complications such as insulin resistance, type 2 diabetes and cardiovascular disease. Thus, the immune cell-adipocyte crosstalk in the AT is an important regulator of AT function and systemic metabolism. We discuss herein this crosstalk with a special focus on the role of innate immune cells in AT inflammation and metabolic homeostasis in obesity.
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