Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 250, Issue -, Pages 31-38Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.resp.2018.01.015
Keywords
Rabbit; Hypoglossal nerve stimulation; Obstructive sleep apnea; Upper airway
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Funding
- National Institutes of Health, Stimulating Peripheral Activity to Relieve Conditions (SPARC) [1U18EB021792]
- National Heart, Lung and Blood Institute [HL07913]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development Service [1I21RX002041]
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We tested the functional effects of hypoglossal (CNXII) stimulation in the anesthetized rabbit before and after injections of saline into the tongue base to obstruct the airway. Data (n = 6) show little or no effect of CN XII trunk stimulation; however, medial branch stimulation (20-100 Hz; 50-500 mu s pulse width, and incremental increases from 10 mu A) reduced upper airway resistance. Medial branch stimulation was less effective in reducing resistance than anterior advancement of the hyoid. Endoscopic viewing (n-3) of the retropalate showed this region as the narrowest and dynamically changed by anterior hyoid displacement, with less evident effects than CNXII stimulation. We conclude that under these conditions CNXII medial branch stimulation reduces airway resistance, especially after induced obstruction.
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