Journal
RESEARCH IN VETERINARY SCIENCE
Volume 117, Issue -, Pages 271-276Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2017.12.023
Keywords
Liver flukes; Clonorchis sinensis; Opisthorchis viverrini; Trematodes; Virulence and immunomodulation-related genes
Categories
Ask authors/readers for more resources
A total of 71 virulence and immunomodulation-related transcripts (VIRs) of Fasciola hepatica have been previously proposed (Hacariz et al., 2015). In an attempt to further refine this cohort, an in silica meta analysis approach was carried out using publicly available sequence data of related liver flukes, Clonorchis sinensis and Opisthorchis viverrini. Data of both liver flukes were investigated in terms of sequential homology with data of non-parasitic organisms, pathogens and VIRs of F. hepatica, directional selection (Ka/Ks), and cytokine signaling relation (protein motif based). Some VIRs of F. hepatica [showing homology with immune receptors (for toll/interleukin-1, TGF-beta or TNF-alpha), TGE-beta, TNF-alpha, CD147, or relation with suppressors of cytokine signaling/IKBKE 1 or stimulation of TGF-beta (through thrombospondin similarity)] were found to be orthologous with those of both C. sinensis and O. viverrini. The in silica analysis indicates that on the basis of genetic commonality, a total of 30 VIRs of F. hepatica are highlighted as of foremost importance in the parasite evasion strategy, through controlling of host immune system. Findings in this study could be important to further enhance our understanding of the parasitic mechanisms and develop effective control strategies against F. hepatica and other related parasites.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available