Journal
RESEARCH IN MICROBIOLOGY
Volume 169, Issue 2, Pages 61-66Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2017.12.003
Keywords
Cfr; Cfr-like enzymes; Antibiotic resistance; RNA methylation
Categories
Ask authors/readers for more resources
The Cfr methyl transferase causes an RNA methylation of the bacterial ribosomes impeding reduced or abolished binding of many antibiotics acting at the peptidyl transferase center. It provides multiresistance to eight classes of antibiotics, most of which are in clinical and veterinary use. The cfr gene is found in various bacteria in many geographical locations and placed on plasmids or associated with transposons. Cfr-related genes providing similar resistance have been identified in Bacillales, and now also in the pathogens Clostridium difficile and Enterococcus faecium. In addition, the presence of the cfr gene has been detected in harbours and food markets. (C) 2018 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available