Journal
REPRODUCTIVE TOXICOLOGY
Volume 75, Issue -, Pages 49-55Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2017.11.003
Keywords
Cadmium; Pregnancy; Birth outcomes; Sex-specific; E-waste
Categories
Funding
- Natural Science Foundation of China [21577084]
- U.S. National Institute of Environment Health Sciences [NIH 1RC4ES019755-01]
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This study was to investigate whether exposure to cadmium (Cd) during pregnancy is associated with an increased risk of adverse birth outcomes in a sex-dependent manner. Cd concentrations in maternal urine (U-Cd) samples were measured in 237 subjects from Guiyu (e-waste area) and 212 subjects from Haojiang. A significance level of p <0.05 was used for all analyses. The maternal U-Cd levels in Guiyu residents were significantly higher than Haojiang. We found significant inverse associations between U-Cd concentrations and birth anthropometry (birth weight, birth length, Head Circumference and Apgar scores with 1 min and 5 mins) in female neonates, but no significant associations were observed in male neonates except Apgar (1 min) score after adjustment. The association was more pronounced among female neonates than male neonates, suggesting an association between Cd and adverse birth outcomes may be sex-specific. (C) 2017 Elsevier Inc. All rights reserved.
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