Journal
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
Volume 16, Issue -, Pages -Publisher
BIOMED CENTRAL LTD
DOI: 10.1186/s12958-018-0352-z
Keywords
Polycystic ovary syndrome; Overweight; Obesity; GnRH antagonist protocol; Frozen embryo transfer; Pregnancy outcomes
Categories
Funding
- National Natural Science Foundation of China [81270868]
- Innovation of Science and Technology Commission of Guangzhou, China [201604020075]
- Department of Science and Technology of Guangdong, China [2016A020218012]
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Background: Overweight/obese women with polycystic ovary syndrome (PCOS) are at increased risk of subfertility and complications of pregnancy, compared with normal-weight women. To implement controlled ovarian hyperstimulation (COH), the improved efficacy of the gonadotrophin-releasing hormone antagonist (GnRH-ant) protocol has been demonstrated, as well as frozen embryo transfer (FET). Objective: This retrospective study evaluated the pregnancy outcomes after combined GnRH-ant protocol and FET in overweight/obese women with PCOS, with reference to that of normal-weight women with PCOS. Methods: Women with PCOS (n = 398) who underwent the GnRH-ant protocol for COH followed by FET, were stratified as normal-weight (BMI < 24 kg/m(2)) or overweight/obese (BMI >= 24 kg/m(2)). The outcomes of pregnancy were compared. Results: The overweight/obese patients had significantly lower rates of embryo implantation (47.7%), live birth (47.8%), and live births of twins (10.9%) compared with the normal-weight group (58.4%, 60.8%, and 30.0%, respectively; P = 0.006, 0.015, and 0.000), while the rate of late abortion was significantly higher (11.0% cf. 3.8%, P = 0.030). BMI was the only significant factor affecting the probability of live birth. Conclusion: The pregnancy outcomes of overweight/obese women with PCOS after COH via the GnRH-ant protocol and FET remained at a significant deficit compared with that of normal-weight women with PCOS.
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