Journal
REGULATORY TOXICOLOGY AND PHARMACOLOGY
Volume 95, Issue -, Pages 385-394Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2018.04.015
Keywords
Beta-cypermethrin; Female reproductive function; Mice
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Funding
- Foundation for Fostering Talents of Hainan Medical University [HY2014-025]
- Natural Science Foundation of Hainan Province [20158277, 817130]
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This study aimed to investigate the effects of beta-cypermethrin (beta-CYP) on female reproductive function and examine the morphology of the uterine endometrium and follicular development. The results found that the rate of successful pregnancy in the beta-CYP-treated groups significantly decreased. The levels of serum E-2 and FSH were significantly increased in the beta-CYP-treated groups. The concentrations of serum P and LH were significantly decreased in the beta-CYP-treated groups. The uterine endometrium was damaged and the endometrial pinopode was markedly inhibited. In addition, the total number of follicles of all types was significantly lower in the medium- and high-dose beta-CYP-treated groups. These results suggest that beta-CYP significantly affected the reproductive function of female mice. beta-CYP may have significantly decreased the fertility of female mice by disturbing the reproductive hormone concentrations and inhibiting the development of the endometrium and the endometrial pinopode.
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