Journal
TRANSCRIPTION-AUSTIN
Volume 4, Issue 4, Pages 167-171Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.25777
Keywords
basal repression; unliganded receptor; SRA; progesterone gene-regulation; cell proliferation
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Funding
- Departament d'Innovacio Universitat i Empresa (DIUiE), Ministerio de Educacion y Ciencia (MEC) [BFU2010-01531, BFU2011-28587]
- I3 Program
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In breast cancer cells the Steroid Receptor RNA Activator (SRA) acts as scaffold of a complex containing HP1 gamma, LSDI, HDACl/2 and CoREST, which contributes to repression of key hormone-inducible genes that must be kept silent in the absence of hormone.
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