Journal
TRANSCRIPTION-AUSTIN
Volume 4, Issue 1, Pages 13-17Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/trns.22542
Keywords
BRD4; BET protein; Atypical kinase; RNA Polymerase II; CTD kinase; P-TEFb
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Funding
- Intramural Research Program of the NIH, National Cancer Institute, Center for Cancer Research
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The bromodomain protein BRD4 links cell cycle and transcription, bookmarking active genes during mitosis and serving as a scaffold for transcription factors. Our recent discovery that BRD4 is a RNA Polymerase II CTD kinase identifies a novel transcriptional function. Here we discuss our model in the context of current knowledge.
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