Journal
NATURE REVIEWS IMMUNOLOGY
Volume 13, Issue 1, Pages 46-57Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri3344
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Funding
- US National Institutes of Health [U54 AI081680, U54 AI057159, U19 AI083019]
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Over the past few years, several groups have identified new genes that are transcriptionally induced downstream of type I interferon (IFN) signalling and that inhibit infection by individual or multiple families of viruses. Among these IFN-stimulated genes with antiviral activity are two genetically and functionally distinct families - the IFN-induced protein with tetratricopeptide repeats (IFIT) family and the IFN-induced transmembrane protein (IFITM) family. This Review focuses on recent advances in identifying the unique mechanisms of action of IFIT and IFITM proteins, which explain their broad-spectrum activity against the replication, spread and pathogenesis of a range of human viruses.
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