Journal
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
Volume 12, Issue 1, Pages 17-25Publisher
BENTHAM SCIENCE PUBL
Keywords
N-acylethanolamines; dietary fat; ethanolamine; ethanol; tissue levels; rat; human
Categories
Funding
- Augustinus Foundation
- Carlsberg Foundation
- Novo Nordisk Foundation
- UNIK program: Food Fitness and Pharma for Health and Diseases
- Danish Ministry of Science, Technology, and Innovation
- Novo Nordisk Fonden [NNF11OC1015218] Funding Source: researchfish
Ask authors/readers for more resources
Palmitoylethanolamide (PEA) as well as the other N-acylethanolamines (NAEs), e.g. anandamide, oleoylethanolamide, stearoylethanolamide and linoleoylethanolamide, appear to exist in every mammalian cell at low levels, e.g. a few hundred pmol/g tissue for PEA. Their formation can be stimulated by cellular injury and inflammation. In the brain PEA and other NAEs may have neuroprotective functions. PEA levels in tissues seem hardly to be influenced by variation in intake of dietary fatty acids, except in the small intestine where dietary fat results in decreased levels of PEA and other NAEs. In rat small intestine, PEA, oleoylethanolamide and linoleoylethanolamide have anorectic properties. Of other dietary components, only ethanol is known to influence tissue levels of PEA. Thus, an acute intoxicating dose of ethanol will decrease PEA levels in various areas in the brain of rats. The mechanism behind this effect is not known.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available