Journal
JOURNAL OF BIOMEDICAL RESEARCH
Volume 27, Issue 2, Pages 135-144Publisher
NANJING MEDICAL UNIV
DOI: 10.7555/JBR.27.20120076
Keywords
bisphenol A (BPA); spermatogenesis; apoptosis; testosterone
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Funding
- Major State Basic Research Development Program of China [2009CB941701, 11KJB310003, 2010NJMUZ26]
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Bisphenol A (BPA), an estrogenic chemical, has been shown to reduce sperm count; however, the underlying mechanisms remain unknown. Herein, we show that oral administration of BPA (2 mu g/kg) for consecutive 14 days in adult rats (BPA rats) significantly reduced the sperm count and the number of germ cells compared to controls. The serum levels of testosterone and follicle-stimulating hormone (FSH), as well as the level of GnRH mRNA in BPA rats were lower than those of control rats. Testosterone treatment could partially rescue the reduction of germ cells in BPA rats. Notably, the number of apoptotic germ cells was significantly increased in BPA rats, which was insensitive to testosterone. Furthermore, the levels of Fas, FasL and caspase-3 mRNA in the testicle of BPA rats were increased in comparison with controls. These results indicate that exposure to a low dose of BPA impairs spermatogenesis through decreasing reproductive hormones and activating the Fas/FasL signaling pathway.
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