Journal
PSYCHIATRY RESEARCH
Volume 262, Issue -, Pages 328-332Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2017.01.006
Keywords
Meditation; Anxiety; Resilience; Stress reactivity; Acute stress; Mindfulness-based intervention; Psychological stress
Categories
Funding
- Harvard Clinical and Translational Science Center (NIH) [UL1 RR 025758]
- Harvard University
- NATIONAL CENTER FOR COMPLEMENTARY & ALTERNATIVE MEDICINE [K23AT004432] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [UL1RR025758] Funding Source: NIH RePORTER
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Mindfulness-Based interventions have increased in popularity in psychiatry, but the impact of these treatments on disorder-relevant biomarkers would greatly enhance efficacy and mechanistic evidence. If Generalized Anxiety Disorder (GAD) is successfully treated, relevant biomarkers should change, supporting the impact of treatment and suggesting improved resilience to stress. Seventy adults with GAD were randomized to receive either Mindfulness-Based Stress Reduction (MBSR) or an attention control class; before and after, they underwent the Trier Social Stress Test (TSST). Area-Under-the-Curve (AUC) concentrations were calculated for adrenocorticotropic hormone (ACTH) and pro-inflammatory cytokines. MBSR participants had a significantly greater reduction in ACTH AUC compared to control participants. Similarly, the MBSR group had a greater reduction in inflammatory cytokines' AUC concentrations. We found larger reductions in stress markers for patients with GAD in the MBSR class compared to control; this provides the first combined hormonal and immunological evidence that MBSR may enhance resilience to stress.
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