Journal
PSYCHIATRY INVESTIGATION
Volume 15, Issue 6, Pages 593-601Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
DOI: 10.30773/pi.2017.12.17
Keywords
Depressive disorder; Uric acid; Oxidative stress; Antioxidants; White matter; Neuroimaging
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Funding
- Korean Mental Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea [HM15C 1094, HM15C 1058]
- Basic Science Research Program through National Research Foundation of Korea (NRF) - Ministry of Education [NRF-2017R1D1A1B03035574]
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Objective Uric acid is a non-enzymatic antioxidant associated with depression. Despite its known protective role in other brain disorders, little is known about its influence on the structural characteristics of brains of patients with major depressive disorder (MDD). This study explored the association between uric acid and characteristics of white matter (WM) in patients with MDD. Methods A total of 32 patients with MDD and 23 healthy controls (HCs) were examined. All participants were scored based on the Beck Depression Inventory and Beck Anxiety Inventory at baseline. All patients were also rated with the Hamilton Depression Rating Scale. We collected blood samples from all participants immediately after their enrollment and before the initiation of antidepressants in case of patients. Tract-based spatial statistics were used for all imaging analyses. Results Lower fractional anisotropy (FA) and higher radial diffusivity (RD) values were found in the MDD group than in the HC group. Voxelwise correlation analysis revealed that the serum uric acid levels positively correlated with the FA and negatively with the RD in WM regions that previously showed significant group differences in the MDD group. The correlated areas were located in the left anterior corona radiata, left frontal lobe WM, and left anterior cingulate cortex WM. Conclusion The present study suggests a significant association between altered WM conne, tivity and serum uric acid levels in pa- tients with M1)1), possibly through demyelination.
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