Journal
JOURNAL OF BONE ONCOLOGY
Volume 2, Issue 1, Pages 47-57Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jbo.2012.11.002
Keywords
Bone metastasis; Cancer; Bone microenvironment; Bone remodelling
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Funding
- Prostate Cancer Foundation of Australia (PCFA)
- University of Sydney Cancer Research Fund
- National Health and Medical Research Council, Australia (NHMRC) [535903, 427601, 352332, 596870]
- Australian Cancer Research Foundation
- RT Hall Trust
- Petre Foundation
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The bone microenvironment provides a fertile soil for cancer cells. It is therefore not surprising that the skeleton is a frequent site of cancer metastasis. It is believed that reciprocal interactions between tumour and bone cells, known as the vicious cycle of bone metastasis support the establishment and orchestrate the expansion of malignant cancers in bone. While the full range of molecular mechanisms of cancer metastasis to bone remain to be elucidated, recent research has deepened our understanding of the cell-mediated processes that may be involved in cancer cell survival and growth in bone. This review aims to address the importance of the bone microenvironment in skeletal cancer metastasis and discusses potential therapeutic implications of novel insights. Crown Copyright (C) 2012 Published by Elsevier GmbH. All rights reserved.
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