Journal
NATURE REVIEWS CANCER
Volume 13, Issue 2, Pages 97-110Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3447
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Funding
- VIB
- Fonds Wetenschappelijk Onderzoek, Belgium
- geconcerteerde onderzoeksacties of Ghent University, Belgium
- Stichting tegen Kanker
- Association for International Cancer Research, UK
- EU-FP7 framework program [TuMIC 2008-201662]
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Epithelial to mesenchymal transition (EMT) is essential for driving plasticity during development, but is an unintentional behaviour of cells during cancer progression. The EMT-associated reprogramming of cells not only suggests that fundamental changes may occur to several regulatory networks but also that an intimate interplay exists between them. Disturbance of a controlled epithelial balance is triggered by altering several layers of regulation, including the transcriptional and translational machinery, expression of non-coding RNAs, alternative splicing and protein stability.
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