Journal
PROTEOMICS CLINICAL APPLICATIONS
Volume 12, Issue 5, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/prca.201700142
Keywords
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Funding
- National Institutes of Health [P30GM110759, U54GM115677, P30AI042853, K24HD080539]
- Lifespan Pilot Research Fund [701-5857]
- Rhode Island Foundation Medical Research Grant [20133969]
- NIH COBRE URI/RIH Pilot Research Grant [P20GM104317]
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Exosomes are 30-100nm extracellular vesicles secreted from late endosomes by various types of cells. Numerous studies have suggested that exosomes play significant roles in human immunodeficiency virus 1 (HIV-1) biogenesis. Proteomics coupled with exosome fractionation has been successfully used to identify various exosomal proteins and helped to uncover the interactions between exosomes and HIV-1. To inform the current progress in the intersection of exosome, proteomics, and HIV-1, this review is focused on: i) analyzing different exosome isolation, purification methods, and their implications in HIV-1 studies; ii) evaluating the roles of various proteomic techniques in defining exosomal contents; iii) discussing the research and clinical applications of proteomics and exosome in HIV-1 biology.
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