Journal
PROGRESS IN POLYMER SCIENCE
Volume 81, Issue -, Pages 144-162Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.progpolymsci.2018.01.001
Keywords
Electroactive polymers; Conducting polymers; Piezoelectric polymers; Polyelectrolyte gels; Tissue regeneration
Categories
Funding
- National High Technology Research and Development Program of China (863 Program) [2015AA033502]
- National Natural Science Foundation of China [51372087, 51541201, 51673168]
- National Key Research and Development Program of China [2016YFA0100900]
- Science and Technology Planning Project of Guangdong Province, China [2014A010105048]
- Natural Science Foundation of Guangdong Province [2015A030313493, 2016A030308014]
- State Key Laboratory for Mechanical Behavior of Materials, China [20141607]
- Zhejiang Provincial Natural Science Foundation of China [LZ16E030001]
- National Institutes of Health [CA200504, CA195607, EB021339]
- Oklahoma Center for Adult Stem Cell Research [434003]
- NATIONAL CANCER INSTITUTE [R21CA200504, R21CA195607] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING [R01EB021339] Funding Source: NIH RePORTER
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Human body motion can generate a biological electric field and a current, creating a voltage gradient of -10 to -90 mV across cell membranes. In turn, this gradient triggers cells to transmit signals that alter cell proliferation and differentiation. Several cell types, counting osteoblasts, neurons and cardiomyocytes, are relatively sensitive to electrical signal stimulation. Employment of electrical signals in modulating cell proliferation and differentiation inspires us to use the electroactive polymers to achieve electrical stimulation for repairing impaired tissues. Electroactive polymers have found numerous applications in biomedicine due to their capability in effectively delivering electrical signals to the seeded cells, such as biosensing, tissue regeneration, drug delivery, and biomedical implants. Here we will summarize the electrical characteristics of electroactive polymers, which enables them to electrically influence cellular function and behavior, including conducting polymers, piezoelectric polymers, and polyelectrolyte gels. We will also discuss the biological response to these electroactive polymers under electrical stimulation. In particular, we focus this review on their applications in regenerating different tissues, including bone, nerve, heart muscle, cartilage and skin. Additionally, we discuss the challenges in tissue regeneration applications of electroactive polymers. We conclude that electroactive polymers have a great potential as regenerative biomaterials, due to their ability to stimulate desirable outcomes in various electrically responsive cells. (C) 2018 Elsevier B.V. All rights reserved.
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