Journal
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
Volume 80, Issue -, Pages 54-62Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pnpbp.2017.05.025
Keywords
iPSC; Disease modeling; Drug screening; Neurological disorders
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation FAPESP) [2012/50880-4]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq), Brazil
- NARSAD
- NIH [R01MH108528, R01MH109885]
- FAPESP [2016/26189-0]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/50880-4] Funding Source: FAPESP
Ask authors/readers for more resources
Human induced pluripotent stem cells (iPSCs) represent a revolutionary tool for disease modeling and drug discovery. The generation of tissue-relevant cell types exhibiting a patient's genetic and molecular background offers the ability to develop individual and effective therapies. In this review, we present some major achievements in the neuroscience field using iPSCs and discuss promising perspectives in personalized medicine. In addition to disease modeling, the understanding of the cellular and molecular basis of neurological disorders is explored, including the discovery of new targets and potential drugs. Ultimately, we highlight how iPSC technology, together with genome editing approaches, may bring a deep impact on pre-clinical trials by reducing costs and increasing the success of treatments in a personalized fashion.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available