Journal
PROGRESS IN CARDIOVASCULAR DISEASES
Volume 61, Issue 2, Pages 232-245Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.pcad.2018.07.002
Keywords
F-18-fluorocleoxyglucose; Positron-emission tomography; Computed tomography; Browning; Energy balance; Exercise; Pharmacological agents; Dietary compounds; Cold exposure
Categories
Funding
- Spanish Ministry of Economy and Competitiveness
- Retos de la Sociedad [DEP2016-79512-R]
- Fondos Estructurales de la Union Europea (FEDER)
- Spanish Ministry of Education [FPU 13/04365, 16/02828]
- Fundacion Iberoamericana de Nutricion (FINUT)
- Redes tematicas de investigacion cooperativa RETIC [Red SAMID RD16/0022]
- AstraZeneca HealthCare Foundation
- University of Granada, Plan Propio de Investigacion 2016, Excellence actions: Units of Excellence
- Unit of Excellence on Exercise and Health (UCEES)
- Dutch Diabetes Research Foundation [2015.81.1808]
- Dutch Heart Foundation [2009T038]
- Netherlands Cardiovascular Research Initiative
- Dutch Heart Foundation for the GENIUS-II project 'Generating the best evidence-based pharmaceutical targets for atherosclerosis' [CVON2017-20]
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Human brown adipose tissue (BAT) was re-discovered in 2009 by several independent groups, who showed that it is present and active in adults, as judged from the profound uptake of the glucose analogue radiotracer F-18-fluorodeoxyglucose in positron-emission tomography and computed tomography scan analysis after cold exposure. A potential clinical implication of activating BAT relates to its high metabolic activity and its potential role in stimulating energy expenditure (i.e. resting energy expenditure, meal-induced thermogenesis, and cold induced thermogenesis), which makes it an attractive target to reduce adiposity. Moreover, due to its ability to oxidise glucose and lipids, BAT activation may also potentially exert beneficial metabolic and cardiovascular effects through reducing glucose and lipid levels, respectively. This review describes the potential role of human BAT in the prevention and treatment of obesity, metabolism, and cardiovascular disease focusing on its impact on energy expenditure and management of body fat accumulation as well as on glucose and lipid metabolism. This article also summarises the strategies that are currently being studied to activate human BAT. (C) 2018 Elsevier Inc. All rights reserved.
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