Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 138, Issue -, Pages 32-37Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2018.06.007
Keywords
Actin protein; Sequence conservation; Actin orthologs; In situ hybridization; Zebrafish
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Funding
- Heart and Stroke Foundation of Canada [G-15-0008961]
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Zebrafish is rapidly becoming a key model organism for studying a variety of biological processes from molecules to organisms. Interactions involving actin, a contractile protein and part of the cytoskeleton, are regulated by actin binding proteins in the majority of physiological processes in eukaryotic cells. To understand the contribution of actin proteins to the physiological processes of zebrafish, it is important to identify the diverse isoforms of actin encoded by its genome; however, significant sequence identity complicates isoform assignments. Through a combination of human-directed sequence and functional analysis, we have assigned and performed localization of actcic, a previously undesignated cardiac actin gene, and propose an updated assignment of alpha-actin protein isoform identities in zebrafish. (C) 2018 Elsevier Ltd. All rights reserved.
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