Journal
PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
Volume 134, Issue -, Pages 44-49Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pbiomolbio.2017.12.005
Keywords
Aryl hydrocarbon receptor; Bone formation; Bone differentiation; NF-kappa B signaling pathway; Wnts signaling pathway; MAPK signaling pathway
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Funding
- Gansu province health scientific research plan management [GW GL 2014-48]
- National Natural Science Foundation of China [51304101]
- Scientific and Research Project of Institutions of Higher Learning in Gansu Province [2015B-033]
- Youth Science and Technology Fund Project of Gansu Province [1606RJYA305]
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Bone remodeling is a persistent process for maintaining skeletal system homeostasis, and it depends on the dynamic equilibrium between bone-forming osteoblasts and bone-resorbing osteoclasts. Aryl hydrocarbon receptor (Ahr), a ligand-activated transcription factor, plays a pivotal role in regulating skeletal system. In order to better understand the role of Ahr in bone remodeling, we focused on bone remodeling characteristic, and the effects of Ahr on bone formation and differentiation, which suggest that Ahr is a critical control factor in the process of bone remodeling. Moreover, we discussed the impacts of Ahr on several signaling pathways related to bone remodeling, hoping to provide a theoretical basis to improve bone remodeling. (C) 2017 Published by Elsevier Ltd.
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