Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 7, Pages E1627-E1636Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1720855115
Keywords
place cells; grid cells; speed cells; entorhinal cortex; hippocampus
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Funding
- European Research Council (GRIDCODE Grant) [338865]
- Research Council of Norway [226003]
- Research Council of Norway (Centre for Neural Computation Grant) [223262]
- Research Council of Norway (NORBRAIN1 Grant) [197467]
- Kavli Foundation
- European Research Council (ERC) [338865] Funding Source: European Research Council (ERC)
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The mammalian positioning system contains a variety of functionally specialized cells in the medial entorhinal cortex (MEC) and the hippocampus. In order for cells in these systems to dynamically update representations in a way that reflects ongoing movement in the environment, they must be able to read out the current speed of the animal. Speed is encoded by speed-responsive cells in both MEC and hippocampus, but the relationship between the two populations has not been determined. We show here that many entorhinal speed cells are fast-spiking putative GABAergic neurons. Using retrograde viral labeling from the hippocampus, we find that a subset of these fast-spiking MEC speed cells project directly to hippocampal areas. This projection contains parvalbumin (PV) but not somatostatin (SOM)-immunopositive cells. The data point to PV-expressing GABAergic projection neurons in MEC as a source for widespread speed modulation and temporal synchronization in entorhinal-hippocampal circuits for place representation.
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