Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 115, Issue 12, Pages 3174-3179Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1705927115
Keywords
blast disease; broad-spectrum resistance; innate immunity; TPR protein; rice
Categories
Funding
- National Science Foundation of China (NSFC) [31171622, 31571994]
- National Key Research and Development Program of China [2016YFD0100600]
- Transgenic Projects from the Chinese Ministry of Agriculture (TPCMA) [2014ZX0800903B]
- Program for New Century Excellent Talents in University from the Ministry of Education in China [NECT-13-0920]
- Hundred Talents Plan Foundation Youth Foundation Grant [13QNJJ0076]
- NSFC [31601290, 31401351, 31501627]
- National Science Foundation [PGRP IOS 1237975]
- NIH [GM59962]
- US Department of Agriculture National Institute of Food and Agriculture [2017-67013-26590]
- TPCMA [2016ZX08001002]
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Crops carrying broad-spectrum resistance loci provide an effective strategy for controlling infectious disease because these loci typically confer resistance to diverse races of a pathogen or even multiple species of pathogens. Despite their importance, only a few crop broad-spectrum resistance loci have been reported. Here, we report the identification and characterization of the rice bsr-k1 (broad-spectrum resistance Kitaake-1) mutant, which confers broad-spectrum resistance against Magnaporthe oryzae and Xanthomonas oryzae pv oryzae with no major penalty on key agronomic traits. Map-based cloning reveals that Bsr-k1 encodes a tetratricopeptide repeats (TPRs)-containing protein, which binds to mRNAs of multiple OsPAL (OsPAL1-7) genes and promotes their turnover. Loss of function of the Bsr-k1 gene leads to accumulation of OsPAL1-7 mRNAs in the bsr-k1 mutant. Furthermore, overexpression of OsPAL1 in wild-type rice TP309 confers resistance to M. oryzae, supporting the role of OsPAL1. Our discovery of the bsr-k1 allele constitutes a significant conceptual advancement and provides a valuable tool for breeding broad-spectrum resistant rice.
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