Journal
EUROPEAN RESPIRATORY REVIEW
Volume 22, Issue 127, Pages 44-52Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/09059180.00007112
Keywords
Adult onset; asthma; childhood onset; phenotypes; risk factors; treatment
Categories
Funding
- Actelion
- Merck
- Schering Plough
- GSK
- Novartis
- Nycomed
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Asthma that starts in adulthood differs from childhood-onset asthma in that it is often non-atopic, more severe and associated with a faster decline in lung function. Understanding of the underlying mechanism of adult-onset asthma and identification of specific phenotypes may further our understanding of pathophysiology and treatment response, leading to better targeting of both existing and new approaches for personalised management. Pivotal studies in past years have led to sustained progress in many areas, ranging from risk factors for development, identification of different phenotypes, and introduction of new therapies. This review highlights and discusses literature on adult-onset asthma, with special focus on the differences from childhood-onset asthma, risk factors for development, phenotypes of adultonset asthma and new approaches for personalised management.
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